A multi-biomarker approach for improving the accuracy of transient ischemic attack diagnosis

3 days ago 3

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Accurate diagnosis of transient ischemic attacks (TIAs) is challenging. This study was aimed at analyzing blood biomarkers to distinguish TIAs from mimics.

The levels of eight candidate biomarkers were measured in 234 patients with suspected TIA, 103 of whom had TIA and 131 of whom had mimics. We compared the groups, examined the effects of the biomarkers via logistic regression, compared models with likelihood ratio tests, assessed predictive accuracy with receiver operating characteristic analysis, and optimized cutoff values with the PanelomiX algorithm. ApoC-III, IL-6, and vWF were the most effective biomarkers in discriminating TIAs from mimics after adjustment for clinical variables.

The area under the curve was 0.73 for ApoC-III; 0.74 for IL-6; 0.74 for vWF; and 0.72 for the clinical model. The likelihood ratio test indicated that these biomarkers showed better fit than the clinical model: Apo-CIII (P ≤ 0.031), IL-6 (P ≤ 0.030), and vWF (P ≤ 0.040). With the PanelomiX algorithm, a model incorporating biomarker thresholds (Apo-CIII >132.29 ng/mL, IL-6 >5.45 pg/mL, vWF <280.09%, NIHSS score >4.5, and age >41.5 years) achieved a sensitivity of 100% and a specificity of 28% in distinguishing TIAs from mimics.

These findings suggest that combining blood biomarkers with clinical data might potentially enhance TIA diagnosis.

Terms

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

*** Disclaimer: This Article is auto-aggregated by a Rss Api Program and has not been created or edited by Nandigram Times

(Note: This is an unedited and auto-generated story from Syndicated News Rss Api. News.nandigramtimes.com Staff may not have modified or edited the content body.

Please visit the Source Website that deserves the credit and responsibility for creating this content.)

Watch Live | Source Article