For research on dengue, PGI scientist bags IVS — Young Scientist Award

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Dr Priyanka Thakur, a probe idiosyncratic from PGIMER. (Express Photo)

Dr Priyanka Thakur, a probe idiosyncratic from PGIMER, has been awarded the Prestigious ‘IVS — Young Scientist Award 2024’ (Medical) for her archetypal probe enactment connected the ‘Role of NLRP-3 inflammasome and Beclin-1/LC3B autophagy cistron markers successful the mediation of microorganism replication and cytokine tempest successful the severity of dengue patients’. It was awarded astatine the precocious held International Conference of the Indian Virological Society (VIROCON 2024), Gwalior.

Dengue is simply a self-limiting arboviral infection, being transmitted by the Asian Tiger mosquito, the Aedes aegypti, which has a penchant to wound during dawn and dusk, and the circulation of the microorganism is maximum during the post-monsoon play successful northbound India. The transmission of microorganism continues till the atmospheric somesthesia falls beneath 15 degrees Centigrade, coinciding betwixt the archetypal week and 2nd week of December. Because of debased atmospheric temperatures, mosquito breeding falls to a minimum level, thereby halting dengue transmission.

The question that remains unanswered is: wherefore the self-limiting dengue leads successful 5-10 per cent of cases into analyzable dengue successful the signifier of dengue haemorrhagic fever (DHF) oregon dengue daze syndrome (DSS), wherever secondary dengue remains to beryllium a predisposing factor.

The survey revealed that successful terrible dengue cases, determination was important upregulation of NLRP-3 inflammasome cistron and autophagy genes, which paved the mode to knowing the engagement of inflammasome and autophagy genes to aggravate the dengue illness starring to mortality. Thus, blocking the pathways done agents similar 3 MA helped flooded the imaginable ‘cytokine storm’ observed successful terrible dengue patients successful in-vitro experiments.

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