‘I am no longer injecting my son’s blood’: Tech entrepreneur Bryan Johnson switches to Total Plasma Exchange therapy for advanced age reversal

TPE therapy, Johnson explained, is gaining attraction for its potential successful longevity science. “TPE is an precocious longevity therapy with large effects successful removing toxins, discarded products, aged misfolded and glycated proteins, and immune complexes,” helium noted, adding that it has shown committedness successful delaying and reversing age-related diseases, including dementia, portion besides reducing biologic age. Johnson’s clasp of this cutting-edge therapy reflects the increasing involvement successful experimental interventions to amended wellness and widen lifespan. 

Experts person explored the effectiveness of antithetic TPE protocols, highlighting the imaginable of bi-weekly TPE combined with IVIG to output the highest biologic property reductions. However, respective limitations and unanswered questions remain. To amended recognize this analyzable and evolving area, we contacted an adept for insights.

How does Total Plasma Exchange (TPE) enactment to trim biologic age?

Dr Palleti Siva Karthik Reddy, advisor interior medicine astatine Koshys Hospitals, tells indianexpress.com, “One of the cardinal mechanisms done which TPE is believed to trim biologic property is by lowering systemic inflammation. AgEing is intimately linked to chronic inflammation, often called inflammaging, which contributes to cellular harm and dysfunction. By removing pro-inflammatory cytokines specified arsenic IL-6 and TNF-α, TPE whitethorn assistance reconstruct a much youthful immune profile.”

Another projected mechanism, helium says, is the clearance of senescence-associated proteins, including beta-2 microglobulin, which accumulates with property and has been linked to cognitive decline. “TPE whitethorn besides amended vascular relation by reducing oxidative accent and promoting amended circulation, which is important for organ wellness and longevity. Additionally, the resetting of immune compartment populations done TPE whitethorn play a relation successful slowing down the aging process by reducing the load of dysfunctional immune cells. However, portion these mechanisms are promising, it is important to enactment that overmuch of the grounds remains preliminary, and much probe is needed to found TPE’s semipermanent effects connected ageing.”

I americium nary longer injecting my son’s blood.

I’ve upgraded to thing else: full plasma exchange.

Steps:
1. Take retired each humor from body
2. Separate plasma from blood
3. Replace plasma with 5% albumin & IVIG

Here’s my container of plasma. Who wants it?
🧵 pic.twitter.com/rUScTIDea6

— Bryan Johnson /dd (@bryan_johnson) January 28, 2025

Role IVIG plays successful enhancing the outcomes of TPE

Intravenous Immunoglobulin (IVIG) is often utilized successful conjunction with TPE to reconstruct immune equilibrium and forestall imaginable antagonistic effects caused by the removal of plasma. During TPE, not lone are harmful substances removed from circulation, but indispensable immune components specified arsenic antibodies and regulatory proteins whitethorn besides beryllium depleted. “IVIG serves to replenish these immunoglobulins, thereby supporting immune relation and reducing the hazard of infections oregon immune dysregulation that whitethorn hap post-TPE,” informs Dr Reddy. 

Additionally, helium mentions that IVIG has its anti-inflammatory properties, which whitethorn further lend to the rejuvenation effects attributed to TPE. It is believed to modulate cytokine activity, reducing excessive immune activation portion promoting a much balanced immune response. “This could beryllium peculiarly important successful bi-weekly TPE protocols, wherever predominant plasma speech whitethorn pb to excessive depletion of protective immune factors. IVIG whitethorn assistance prolong the biologic property reductions observed with TPE by restoring immune homeostasis and perchance enhancing regenerative processes. However, it remains unclear whether IVIG unsocial has autarkic anti-aging effects oregon if its relation is chiefly supportive successful the discourse of TPE,” helium stresses. 

Risks and imaginable broadside effects of undergoing predominant TPE with IVIG

While TPE and IVIG are mostly considered harmless erstwhile utilized for aesculapian purposes, predominant usage of these therapies successful different steadfast individuals carries imaginable risks. Dr Reddy explains, “One interest is the depletion of indispensable proteins and electrolytes, which tin pb to imbalances that impact assorted physiological functions. Removing plasma excessively often whitethorn besides trim beneficial antibodies and clotting factors, perchance expanding the hazard of infections oregon bleeding disorders.”

Another hazard associated with predominant TPE is cardiovascular strain, helium continues. “The process of plasma speech involves important fluid shifts, which tin origin fluctuations successful humor unit and summation the hazard of hypotension, particularly successful individuals with underlying cardiovascular conditions. IVIG, connected the different hand, tin sometimes trigger allergic reactions, headaches, fever, and, successful uncommon cases, much superior immune complications. Given these imaginable risks, it is important for individuals considering predominant TPE with IVIG to acquisition thorough aesculapian valuation and continuous monitoring to guarantee that the process does not pb to unintended wellness consequences,” says Dr Reddy. 

DISCLAIMER: This nonfiction is based connected accusation from the nationalist domain and/or the experts we spoke to. Always consult your wellness practitioner earlier starting immoderate routine.