T-cell based dengue vaccine PRAHR wins best innovation award at GBU-Biothon

Researchers judge the innovative thought holds immense committedness for tackling a wide scope of diseases including cancer done cutting-edge immunoengineering technologies.

Dengue virus, which is the causative cause of dengue fever transmitted by Aedes mosquitoes, infects cells of immune strategy namely dendritic cells and macrophages. Most individuals infected, retrieve with small to nary complications and make important immunity against the infecting viral serotype.

“However, erstwhile exposed to different serotype of the microorganism (dengue microorganism has 4 serotypes, DENV 1-4) these individuals are astatine an accrued hazard of processing terrible disease, a information that clinicians telephone antibody-dependent illness enhancement oregon ADE. The archetypal lawsuit of viral infection, usually by a azygous serotype, culminates successful the secretion of antibodies by B-cell activation, and the eventual elimination of the microorganism from the system. Thus, rendering the idiosyncratic immune to the serotype encountered,” explains Dr Kumar.

Prof Rakesh Rawal, caput of section Medical Biotechnology GBU told this paper, “A large complication arises astatine the clip of 2nd corruption by different serotype, erstwhile antibodies generated successful the archetypal lawsuit hindrance to viral antigens with a overmuch little affinity. The beingness of these “low affinity” antibodies prevents clearance of the microorganism by agglutination and increases their uptake by immune cells possessing frankincense expanding the viral uptake and severity of infection.”

Further adding, Prof Rawal said, “Secondary dengue infections are often associated with pneumonia and death…Currently, determination are lone 2 dengue vaccines disposable and some being unrecorded vaccines person large information concerns associated with their use…”

To place potent TCR sequences, the radical of 4 students-Nachiket Waman, Tanish Kumar, Karishma Mistry, Achal Nawghade-combined multi-serotype viral antigen recognition with affinity-based enrichment of reactive T cells obtained from individuals with superior infection.

“The radical ideated a caller and unsocial attack to tackle a large wellness interest by employing cutting-edge immunoengineering technologies and impressed the sheet of manufacture experts judging the event. Thus, winning america the Award for Best Societal Impact astatine Biothon 2025,” Nachiket Waman, carnal biotechnology postgraduate pupil said.