Vaccine horror as woman, 23, claims she was left temporarily BLIND and with agonizing bruises all over her body after reaction to 'superdose'

A Florida pistillate claims she was near temporarily unsighted and with agonizing swelling and bruising aft doctors forced her to instrumentality vaccines for a uncommon humor disease. 

Alexis Lorenze, 23, was diagnosed with Paroxysmal Nocturnal Hemoglobinuria (PNH) successful January, a one-in-a-million autoimmune information which causes the body's immune strategy to onslaught her reddish humor cells. 

Ms Lorenze traveled to California earlier this period for a transfusion to replenish the damaged cells, wherever she claims doctors astatine UCI Medical refused to administer it unless she received vaccines for tetanus, pneumonia, and meningitis 'all astatine once.' 

But she claims wrong 10 minutes, her imaginativeness went acheronian successful some eyes, her jaw locked successful place, and she started vomiting. She has besides suffered hemorrhaging nether her tegument and terrible swelling. 

Doctors told DailyMail.com that 'it's asking for trouble' to springiness a diligent truthful galore vaccines astatine erstwhile once they person an autoimmune information similar PNH, arsenic it tin trigger a 'disastrous' and perchance 'life-threatening' response. 

This is due to the fact that utmost immune overreactions, besides known arsenic cytokine storms, tin pb to the assemblage attacking different steadfast organs and humor proviso to them getting chopped off. This tin pb to perchance irreversible organ harm and death.  

However, they noted it's improbable the components successful the vaccines themselves pb to Ms Lorenze's condition. 

Rather, it's much apt her unwellness was not nether power and flared up successful effect to the vaccines, arsenic they tin trigger immune responses successful patients with PNH.

Dr Stuart Fischer, an interior medicine doc successful New York, told DailyMail.com: 'To springiness 3 vaccines - adjacent 1 - I consciousness is simply a small spot risky.'

It's unclear precisely wherefore the infirmary allegedly wanted to springiness her the vaccines instantly astatine the aforesaid time.

Dr Raj Dasgupta, main aesculapian advisor for Fortune Recommends Health, told DailyMail.com: 'While it’s usually harmless for astir radical to get these vaccines together, successful her case, the immune effect could person been excessively overmuch and led to complications.

'To debar overloading her system, it would beryllium tenable to abstraction retired the vaccines and intimately show for immoderate worsening symptoms.'

Several of these vaccines, specified arsenic meningitis, are required successful US schools, portion others similar tetanus are recommended each 10 years and aft suffering a puncture wound. 

The pneumonia vaccine, however, is lone recommended for young children, older adults, and those who are immunocompromised, arsenic these groups are much susceptible to the illness. 

DailyMail.com has reached retired to UCI Medical and Ms Lorenze's household for comment, but has not received a effect from either. 

In a bid of viral TikTok videos, Ms Lorenze claims she was diagnosed with PNH successful January 2024. This is caused by an acquired mutation of the PIGA gene, which damages reddish humor cells. 

Normally, reddish humor cells assistance transportation oxygen from the lungs to different parts of the assemblage utilizing the macromolecule hemoglobin. 

But successful patients with PNH, hemoglobin cannot typically interruption down, truthful the macromolecule overwhelms organs similar the kidneys and tin pb to humor clots, which tin crook into strokes oregon bosom attacks. 

Ms Lorenze claims she had not received immoderate vaccines since childhood. 

She is 1 of the astir 14,000 Americans who person reported vaccine injuries to the Health Resources and Services Administration’s Countermeasures Injury Compensation Program (CICP).

A video connected Ms Lorenze's Facebook shows a speech betwixt her and a pistillate identified arsenic a nurse. 

In the video, the alleged aesculapian nonrecreational said doctors bash not judge her information is an allergic absorption but alternatively the effect of her information being aggravated by the vaccines. 

Dr Paul Offit, manager of the Vaccine Education Center astatine Children's Hospital of Philadelphia, told DailyMail.com portion helium was not comfy commenting connected Ms Lorenze's lawsuit specifically, terrible effects similar these are apt not owed to the vaccines themselves. 

'If thing happens immediately, similar wrong 5 minutes, it's usually an allergic reaction,' helium said. 'It's not due to the fact that of the vaccine itself. It's due to the fact that of possibly a constituent of the vaccine that causes an allergic reaction.'

Dr Fischer besides noted it appears to beryllium PNH itself reacting to the vaccines but suggested the alleged 'superdose' could beryllium peculiarly unsafe for a diligent with this condition.  

'In idiosyncratic with an immune-related illness, it could beryllium disastrous,' helium said. 

Dr Gloria Gerber, a hematologist and adjunct prof astatine Johns Hopkins School of Medicine, told DailyMail.com that it's imaginable that the vaccines could person exacerbated Ms Lorenze's PNH by accelerating the breakdown of reddish humor cells. 

A hazard of giving truthful galore vaccines oregon medications astatine erstwhile is that successful the lawsuit of a reaction, it tin beryllium hard to corroborate which 1 was the culprit. 

Dr Fischer gave the illustration of a diligent receiving 3 medications astatine once: 'You springiness them each successful 1 day, and the adjacent day, the diligent has a reaction? Which of those 3 things caused the reaction? 

'Unfortunately, the diligent has to beryllium considered allergic to each 3 medications astatine once.

'Giving 3 vaccines astatine once, honestly, I don't deliberation I've heard of astatine all. What's the hurry? What's the exigency of giving the 3 vaccines astatine erstwhile once you could bash 1 and hold a small bit? She's evidently precise delicate due to the fact that of her illness.

'Doing aggregate things astatine the aforesaid clip is precise risky business, and risky concern has nary spot successful medicine.'

According to the Aplastic Anemia and MDS International Foundation (AAMDS), patients with PNS should person regular vaccines, arsenic humor transfusions tin weaken the immune system. 

Routine vaccinations typically see those for MMR, flu, HPV, tetanus, and hepatitis, among others, according to the CDC. 

Ms Lorenze's household claims the doctors told them the vaccines were required for her to person the transfusion. It's unclear however soon they planned to bash the transfusion after. 

'I don't spot wherefore you would request to beryllium vaccinated for a transfusion,' Dr Gerber said, arsenic vaccines are not typically required for this treatment. 

However, shots for conditions similar meningitis and sometimes pneumonia are typically required for PNH's modular treatment, complement inhibitors. 

This is an immunotherapy utilized support the immune strategy from destroying reddish humor cells. 

She noted the infirmary whitethorn person been readying to commencement Ms Lorenze connected complement inhibitors, which could punctual the vaccine requirement, arsenic the attraction leaves PNH patients much susceptible to definite infections. 

Additionally, she said if patients are experiencing symptoms similar anemia that are terrible capable to necessitate a humor transfusion, this would beryllium an denotation to commencement complement inhibitors, and 'you privation to commencement a complement inhibitor urgently' if determination is simply a complication similar humor clots. 

This could person been a crushed down the urgency to springiness Ms Lorenze the vaccines astatine once. 

However, vaccines - on with factors similar corruption and gestation - are known to trigger utmost immune responses successful PNH patients who are not being treated with complement inhibitors. 

It's each possible, Dr Gasgupta said, that Ms Lorenze's information could person thing to bash with the vaccines astatine all. 

'There’s besides the anticipation that what she’s experiencing isn’t conscionable from the vaccines,' helium said. 

'PNH tin flare up connected its own, and we person to see whether the information itself is down her terrible reaction.

'Both factors (her PNH and the vaccines) request to beryllium cautiously weighed erstwhile looking astatine what’s happening.'

Ms Lorenze besides claims she temporarily went unsighted instantly aft the vaccines were administered. 

Dr Offit noted that portion immoderate patients whitethorn faint aft a vaccine oregon go lightheaded, 'I haven't heard blindness associated with an allergic reaction,' if that is what happened. 

'Her humor unit mightiness person gone down, which is understandable successful having a absorption to immoderate this is, ' Dr Fischer said. 'If she has mean humor pressure, humor nonaccomplishment [from her condition] could marque her dizzy, and she mightiness adjacent get adjacent fainting.'

'Near fainting tin often origin momentary ocular loss. There's thing intrinsic successful the vaccine that causes blindness.' 

The imaginativeness loss, however, could person been triggered by PNH itself. Dr Gerber noted that 'one of the astir devastating complications successful PNH is thrombosis,' oregon a humor clot wrong a humor vessel. 

'PNH patients tin get clots successful atypical places,' she noted, specified arsenic abdominal organs similar the liver, the skin, and adjacent the eyes.

Left untreated, these could effect successful liver nonaccomplishment oregon stroke, depending connected the determination of the vessel.

It is imaginable that with PNH, Dr Gerber said, patients whitethorn person thrombosis successful the retinal vas of the eyes oregon a encephalon vessel, which could explicate the imaginativeness changes.

According to Facebook updates from Ms Lorenze's father, Todd Lorenze, the household is trying to determination Ms Lorenze to a backstage infirmary successful Los Angeles. 

Mr Lorenze wrote connected Facebook that his girl is successful 'very bad' pain, though her swelling is going down.