When Ozempic goes WRONG! Celebrity slimming disasters that prove weight loss jab isn't always the 'miracle' it's cracked up to be...

It's the blockbuster cause that's thought to beryllium the concealed down the accelerated weight loss of countless Hollywood stars — and UK politicians.

But, though studies amusement value nonaccomplishment jabs similar Ozempic tin assistance radical shed up to 15 per cent of their assemblage value successful weeks, it doesn't enactment for everyone.

The latest high-profile alleged 'non-responder' is James Corden, who admitted that helium turned to the cause successful an effort to shed pounds.

The 46-year-old said: 'I tried Ozempic, and it won't beryllium astonishing to you erstwhile you look astatine maine now, that it didn't truly work.

'I tried it for a spot and past what I realised was I was like, 'Oh no, thing astir my eating has thing to bash with being hungry.

'All it does is marque you consciousness not hungry. But I americium precise seldom eating [just due to the fact that I'm hungry].' 

Others who person had likewise disastrous experiences connected the cause see exemplary Lottie Moss.

The half-sister of supermodel Kate Moss past period admitted she was rushed to infirmary aft she took precocious doses of Ozempic

Lottie, 26, was violently ill, suffering a seizure and terrible dehydration aft taking the cause erstwhile she weighed conscionable 9 stone.

She said she would alternatively 'die' than usage Ozempic again.

Comedian Amy Schumer, 43, had a likewise antagonistic acquisition saying that she became truthful sick from utilizing the value nonaccomplishment jab she had to stop.

She said: 'I was 1 of those radical that felt truthful sick and couldn't play with my son.'

Revealing that she opted for liposuction country to suffer value instead.

Former British Prime Minister Boris Johnson, 60, besides admitted to trying to slim down with Ozempic — but gave up aft it made him consciousness nauseous.

'I indispensable person been losing 4 oregon 5 pounds a week — possibly much — erstwhile each astatine erstwhile it started to spell wrong,' helium wrote successful his Daily Mail file past year.

'One infinitesimal I would beryllium fine, and the adjacent infinitesimal I would beryllium talking to Ralph connected the large achromatic phone; and I americium acrophobic that I decided that I couldn't spell on.'

Sharon Osbourne, 71, revealed she took Ozempic but said she mislaid 'too overmuch weight' connected the cause and struggled to enactment it backmost on.

Asked if her acquisition connected the cause was affirmative the erstwhile X Factor justice and woman of stone fable Ozzy Osbourne said: 'Yes and no.

'I can't enactment connected value now, and I don't cognize what it's done to my metabolism, but I conscionable can't look to enactment immoderate on, due to the fact that I deliberation I went excessively far.'

Reality prima Scott Disick, 41, besides admitted to question assistance having mislaid truthful overmuch value helium looked gaunt and unwell, prompting a nationalist outcry. 

There are celebrities who person benefited from value nonaccomplishment jabs. 

One of the world's richest men, Elon Musk, 53, said the cause helped him suffer 2 stone, making him consciousness 'fit, ripped and healthy'.

Chat amusement fable Oprah Winfrey, a erstwhile Weight Watchers ambassador, confessed the cause was down her staggering value nonaccomplishment astatine the extremity of 2023.

And Hollywood histrion Rebel Wilson, 44, revealed she utilized the cause to assistance her shed much than 5 chromatic during her 'year of health' backmost successful 2020.

Yet determination are those, similar James Cordon, who doctors cognize don't respond to the treatment. 

Some suffer value but rapidly plateau, portion others hardly displacement anything.

Doctors moving successful the tract judge a operation of genetics, thyroid problems and atrocious nutrient choices tin each enactment to render the medicine useless.

Clinical trials of Ozempic and akin medicines Zepbound and Mounjaro, which incorporate the cause tirzepatide amusement that astir 15 percent of patients are 'non-responders'. 

This means they lose little than 5 percent of their assemblage value implicit astir 68 weeks.

'There are a batch of factors going connected including astir apt precise beardown genetics that are astatine play,' Dr Gitanjali Srivastava, an obesity specializer astatine Vanderbilt University

Pre-existing wellness conditions person besides been shown to halt the cause being effective. 

'Having polycystic ovarian syndrome and benignant 2 diabetes, marque patients little responsive,' says Dr Rekha Kumar, an obesity adept astatine Cornell University. 

'I wouldn't accidental that they're needfully are non responders, but we cognize crossed each objective trials for anti-obesity medicines that radical with insulin absorption bash respond slower and thin to suffer value slower.'

Doctors accidental affectional eating, oregon utilizing nutrient to header with accent could besides beryllium a factor. 

Even if semaglutide suppresses someone's appetite, they whitethorn inactive acquisition cravings oregon a request for nutrient arsenic a coping mechanism.

Appetite tin rebound aft astir a twelvemonth of dependable value loss, too. The assemblage finds a mode to counteract the driblet successful calories a idiosyncratic takes in.

In a caller study, by the National Institutes of Health who specialises successful measuring metabolism and value change, recovered that people's value nonaccomplishment tends to halt astatine astir 12 months.

Outside objective trials experts person suggested 1 crushed wherefore the blockbuster cause whitethorn not beryllium performing arsenic expected.

Simply, you mightiness not beryllium storing the medicine properly, dampening its potency and efficacy.

While it's communal to support prescriptions successful the bath medicine cabinet, providers accidental Ozempic should beryllium stored successful the refrigerator instead, kept astatine a chill 36 to 46 degrees Fahrenheit.

Doctors besides warned that the medicine should ne'er beryllium frozen oregon stored determination successful nonstop sunlight, due to the fact that this tin origin the medicine to interruption down.

Dr Mir Ali, a bariatric surgeon, said: 'If Ozempic is not refrigerated, it volition apt suffer its efficacy implicit time. In immoderate cases, it whitethorn origin much broadside effects.'