Can Semaglutide reduce the risk of Alzheimer’s? A new study offers hope of a therapy option

“Semaglutide showed a little hazard of first-time Alzheimer’s Disease diagnosis oregon Alzheimer’s Disease-related medicine prescriptions compared to insulin, different non-insulin/non-GLP-1RAs and different GLP-1RAs. These results were akin for older patients, some genders, and those with and without obesity. Cumulative incidence curves began to diverge wrong 30 days and continued to abstracted thereafter, indicating semaglutide’s imaginable to hold oregon dilatory Alzheimer’s Disease improvement with sustained effects,” says the study.

Dr (Prof) M. V. Padma Srivastava, chairperson, Neurology, Paras Health, Gurugram says this is simply a important measurement successful probe since it connects metabolic wellness straight with neurodegeneration. “The survey shows that effectual humor glucose absorption and inflammation power are captious successful Alzheimer’s progression,” she says.

What’s the subject down the Semaglutide-Alzheimer’s link?

GLP-1 drugs, including Ozempic, Wegovy and others, enactment by targetting receptors successful the encephalon progressive successful glucose regulation, insulin sensitivity and inflammation reduction. Semaglutide, the progressive constituent successful these drugs, reduces neuro-inflammation, which is commonly linked to Alzheimer’s. It helps stabilise humor sweetener levels, limiting oxidative accent oregon compartment harm and enhancing cellular energy. This enactment tin support neurons from degeneration, a hallmark of Alzheimer’s and different neurodegenerative diseases. The survey adds to our knowing of however humor glucose power via GLP-1 whitethorn connection brain-protective effects.

Would you telephone this a breakthrough survey successful Alzheimer’s and dementia research?

The findings from this survey are ground-breaking arsenic they present a caller therapeutic pathway for treating Alzheimer’s that was traditionally managed with cognitive and manner interventions. By demonstrating that GLP-1 drugs tin mitigate immoderate hazard factors for Alzheimer’s, the survey suggests a dual-purpose usage for these drugs: managing diabetes and offering a preventive mechanics for dementia.

How important is the survey for Indian patients?

India has 1 of the highest planetary rates of Type 2 diabetes, which is associated with a higher hazard of cognitive decline. Since Alzheimer’s rates are besides rising among India’s aging population, this probe could beryllium transformative. For Indian patients, GLP-1 drugs could assistance code some metabolic issues and dementia hazard factors successful a azygous attraction approach. This not lone simplifies diligent attraction but besides makes preventive strategies much accessible.

How communal is Alzheimer’s successful those with Type 2 disease?

People with Type 2 diabetes are astatine a importantly higher hazard of Alzheimer’s owed to chronic insulin resistance, higher levels of inflammation and oxidative accent successful the brain. These pb to impaired glucose metabolism successful the brain, resulting successful cognitive diminution and neuron harm implicit time. GLP-1 drugs tin hold oregon trim dementia symptoms successful diabetic patients, frankincense offering a preventive strategy wherever fewer presently exist.