Grey's Anatomy original cast now: From heartbreaking split to Golden Globes win

It's hard to judge it's been astir 20 years since Grey's Anatomy archetypal debuted connected TV. The aesculapian bid premiered connected March 27, 2005, connected ABC and focused connected the lives of interns and unit astatine the fictional Seattle Grace Hospital.

Created by Shonda Rhimes, the play focussed connected Dr. Meredith Grey documenting her travel from surgical intern to afloat qualified doc to the hospital's main of wide surgery. The bid besides focused connected her chap interns and their respective vocation paths and bittersweet demises.

The amusement wasn't without contention - enforcement producer/writer Elisabeth Finch lied aft she survived a uncommon signifier of bony cancer, mislaid a kidney and adjacent decided to person an termination due to the fact that of treatment.

Like the sanction of the hospital, the formed has changed galore times implicit the years, but determination are 3 formed members who stay from the debut season. The formed has gone connected to triumph Golden Globes, bask respectable careers oregon beryllium fired for inappropriate connection connected the show.

Here is wherever the archetypal formed of Grey's Anatomy are now.

Ellen Pompeo - Meredith Grey

One of 3 lone formed members remaining successful the TV drama, Meredith Grey archetypal entered Seattle Grace Hospital arsenic an intern and is presently the hospital's Chief of General Surgery.

During the show, she has experienced the deaths of her friends, hubby arsenic good arsenic survived a infirmary shooting, level clang and security fraud.

Actress Ellen Pompeo announced successful September 2018 that she would permission the show, but a period aboriginal confirmed she would enactment for the foreseeable future. The relation connected the long-running bid earned her a Screen Actors Guild Award and she is 1 of the highest paid TV actresses.

Meredith has a reduced relation successful the bid and inactive narrates the series. Ellen appeared successful Taylor Swift's Bad Blood euphony video, Grey's Anatomy spin-off Station 19 and RuPaul's Drag Race: All Stars

James Pickens Jr. - Richard Webber

Richard Webber was introduced successful the archetypal occurrence of the bid arsenic the Chief of Surgery. He rapidly formed a enslaved with Meredith having worked with her parent Ellis Grey.

Webber has had his just stock of play implicit the people of the bid - helium struggled with intoxicant addiction, mislaid his wife, was electrocuted and temporarily mislaid his occupation aft helping Meredith perpetrate security fraud.

James Pickens Jr. featured successful the spin-off shows but helium besides appeared connected Curb Your Enthaisum, The X-Files, Roseanne, Yellowstone and The Conners.

Chandra Wilson - Miranda Bailey

The different remaining quality successful the long-running aesculapian drama, Miranda Bailey was dubbed "The Nazi" for her stern demeanor and refusal to instrumentality immoderate nonsense.

She was revealed to beryllium a loving and caring quality who thoroughly supported her interns and stood up to the Chief of Surgery. Miranda fired some Richard and Meredith aft an security fraud incidental but they person since returned to enactment nether her.

A four-time Emmy nominee acknowledgment to her enactment connected Grey's Anatomy, Chandra Wilson has besides appeared connected Sex and the City, The Sopranos and General Hospital.

Sandra Oh - Cristina Yang

Cristina Yang was Meredith's champion person and she was known for being clever and no-nonsense successful her work. Yang near to enactment for the Klausman Institute for Medical Research successful Switzerland and was sparingly referenced successful emails and telephone calls.

Arguably 1 of the series' astir known formed members, Sandra Oh has had a immense vocation since leaving Grey's Anatomy. She was the main prima of deed BBC bid Killing Eve and her 2nd Golden Globe award.

Oh has voiced characters successful animated movies Raya and the Last Dragon and Turning Red, arsenic good arsenic The Sandman, the superhero bid Invincible and The Tiger's Apprentice.

Katherine Heigl - Isobel "Izzie" Stevens

Izzie Stevens was the intern who was revealed to person paid for her acquisition by modelling - and she wasn't ashamed of her past. Izzie fell successful emotion with diligent Denny Duquette, played by Jeffrey Dean Morgan, and risked her vocation to get him a bosom transplant and past had to header with his death.

She besides developed encephalon cancer, joined Alex and was aboriginal fired from Seattle Grace aft the merger with Mercy West Hospital successful play 6. She was told to permission and we didn't spot her again.

Heigl near the bid connected arguable presumption aft she withdrew her sanction from Emmy nominations successful 2008, conscionable 1 twelvemonth aft winning an Emmy for champion supporting actress. She near her storylines and worldly was not capable to triumph an Emmy and blocked different actresses from winning.

She went connected to look successful State of Affairs, Doubt, Suits and Firefly Lane and voiced characters successful the animated films The Nut Job and The Nut Job 2: Nutty by Nature.

Justin Chambers - Alex Karev

The intern evolved from a cocky quality to interim Chief of Surgery implicit the people of 16 seasons. He controversially reunited with Izzie and their twins she conceived utilizing frozen embryos.

Since his exit, Chambers has had a comparatively quiescent career. He played Hollywood icon Marlon Brando successful the Paramount+ bid The Offer which covered the making of The Godfather.

Patrick Dempsey - Derek Shepherd

Known arsenic Dr. McDreamy, Derek famously had a one-night basal with Meredith Grey successful the aviator occurrence but aboriginal got married.

Shepherd died aft helium was deed by a car portion helping the victims of a clang and past was incapable to beryllium saved by a understaff and mediocre aesculapian squad astatine different hospital. Viewers heard Shepherd's thought process passim the occurrence with him incapable to speak.

Reflecting connected his character's death, Patrick Dempsey told PEOPLE, "I'm precise grateful for Grey's Anatomy. It's fixed maine the accidental to bash everything. But astatine the aforesaid time, determination was a cost."

He added: "I deliberation aft a definite play of time, nary substance however overmuch wealth you make, you privation power retired of your ain schedule."

"It had been agelong enough. It was clip for maine to determination connected with different things and different interests," Dempsey added of the decision. "I astir apt should person moved connected a mates of years earlier. I stayed a spot longer than I should have."

Derek Shepherd returned for a fewer episodes during play 17. Since leaving the series, Patrick Dempsey has appeared successful romanticist films Valentine's Day and Bridget Jones's Baby arsenic good arsenic the enactment flick Transformers: Dark of the Moon, fearfulness movie Thanksgiving, Ferrari and the Disney+ movie Disenchanted.

T. R. Knight - George O'Malley

George was a surgical intern astatine the fictional Seattle Grace Hospital and worked his mode up to the level of surgical resident. George O'Malley was an overeager, kind-hearted intern who was successful emotion with Meredith, but aboriginal joined Callie Torres (Sara Ramirez) earlier helium pursued a narration with Izzie.

O'Malley had 1 of TV's astir brutal deaths erstwhile helium was near unrecognisable aft redeeming a pistillate from an oncoming bus. Just arsenic his friends and colleagues realised who helium was, helium flatlined and was declared encephalon dead. He inactive made a astonishment quality successful 2020.

He near the bid owed to mediocre storylines and a breakdown of connection betwixt the showrunners. Knight has since appeared connected The Good Wife The Catch, When We Rise, Genius: Einstein and Genius: Picasso and The Flight Attendant.

Isaiah Washington - Preston Burke

The superb cardiothoracic surgeon made a people arsenic being pugnacious connected George to acceptable an illustration for the different interns. Many volition retrieve his narration with Cristina Yang and jilted her astatine the altar successful heartbreaking scenes.

Washington near successful play 3 due to the fact that helium allegedly utilized a homophobic slur astir castmate Knight. He nevertheless returned successful play 10 to impulse Cristina to permission Washington and instrumentality implicit his infirmary successful Switzerland.

Washington aboriginal appeared successful Bionic Woman, The 100 and successful the 2022 movie Corsicana.